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yeasts and fungi by binding to sterols in the cell membrane. Mycolog-II Dosage and Administration Mycolog-II Cream (Nystatin and Triamcinolone Acetonide Cream) is usually applied to the affected areas twice daily in the morning and evening by gently and thoroughly massaging the preparation into the skin. Nystatin provides specific anticandidal activity to Candida (Monilia) albicans and other Candida species, but is not active against bacteria, protozoa, trichomonads, or viruses. Infrequently, signs and symptoms of steroid withdrawal may occur, requiring supplemental systemic corticosteroids. Rarely, irritation may occur. This preparation is contraindicated in those patients with a history of hypersensitivity to any of its components. Parents of pediatric patients should be advised not to use tight-fitting diapers or plastic pants on a child being treated in the diaper area, as these garments may constitute occlusive dressings. Chronic corticosteroid therapy may interfere with the growth and development of children.

Apothecoristol-Myers Squibb Company Princeton, NJ 08540 USA J4-019D February 1993 Mycolog-II nystatin and triamcinolone koto vt coupon acetonide cream Product Information Product Type human prescription drug label Item Code (Source) Route of Administration topical DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength nystatin (nystatin) nystatin. View All, for Dermatologic Use Only, nOT FOR ophthalmic USE. Adverse Reactions A single case (approximately one percent of patients studied) of acneform eruption occurred with use of combined nystatin and triamcinolone acetonide in clinical studies. It is a yellow to light tan powder with a cereal-like odor, very slightly soluble in water, and slightly to sparingly soluble in alcohol. Laboratory Test If there is a lack of therapeutic response, appropriate microbiological studies (e.g., KOH smears and/or cultures) should be repeated to confirm the diagnosis and rule out other pathogens, before instituting another course of therapy. Dosage AND administration ). Patients should be advised on preventive measures to avoid reinfection. HPA axis suppression, Cushings syndrome, and intracranial hypertension have been reported in children receiving topical corticosteroids. Nystatin is a polyene antimycotic obtained from Streptomyces noursei. A urinary free cortisol test and acth stimulation test may be helpful in evaluating hypothalamic-pituitary-adrenal (HPA) axis suppression due to corticosteroid.

Some of the topical corticosteroids and their metabolites are also excreted into the bile. Because many drugs are excreted in human milk, caution should be exercised during use of this preparation by a nursing woman. Recovery of HPA axis function and thermal homeostasis are generally prompt and complete upon discontinuation of the drug. Carcinogenesis, Mutagenesis, and Impairment of Fertility Long-term animal studies have not been performed to evaluate carcinogenic or mutagenic potential, or possible impairment of fertility in males or females. Pediatric Use In clinical studies of limited number number of pediatric patients ranging in age from two months through 12 years, Mycolog-II cleared or significantly ameliorated the disease state in most patients. Pharmacokinetics, the extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings (see.


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